Outside the hotel, many anti-Trump demonstrators called the New York billionaire businessman a fascist or white supremacist.
Surrounded by the police, the protesters concentrated in Central Park.
Demonstrators chanted: "Donald Trump, go away, racist, sexist, anti-gay."
It was an ugly incident unlike anything seen in presidential politics in decades. Trump denied any responsibility for the clash.
His rallies often attract small groups of protesters, but Friday's was the first at which there may have been as many protesters as supporters.
Relatives of 22 prisoners were protesting outside when they were attacked.
The villagers retained 10 policemen, which later were released.
The protesters are against the construction of a train route.
Public transportation concessionaires are protesting for the presence of illegal transport in Cintalapa.