Since Guzmán's February 2014 arrest, authorities have arrested Héctor Beltrán Leyva, head of the cartel bearing his name, as well as the Juárez Cartel's Vicente Carrillo Fuentes, Knights Templar's Servando "La Tuta" Gómez, and the Zetas' Omar Treviño Morales. Knights Templar leader Nazario Moreno died in a shootout with soldiers.

According to information of the Narcotics Police, the Army and the Intelligence Directorate of Criminal Investigation and Interpol (Dijin) of Colombia obtained by El Tiempo, Ismael "El Mayo" Zambada is in charge of the business in Colombia.

Roberto Saviano, author of "Gomorrah", said that Mexican cartels should be defined as mafia organizations, that can not exist without direct links with politics, entrepreneurs and the judiciary beyond simple bribery and corruption.