The storm is centered about 395 miles (636 kilometers) southwest of Manzanillo, Mexico, and is moving west-northwest near 15 mph (24 kph)
The storm is centered about 280 miles (451 kilometers) west of Cabo San Lázaro, Mexico.
Orlene emerged from a tropical depression early Sunday and is centered about 700 miles (1,125 kilometers) southwest of the southern tip of Baja California, Mexico.
Two bodies were found on a beach, and it is believed they were part of a five-person crew aboard a fishing vessel that was wrecked by the storm.
Early Wednesday, its center was about 55 miles (85 km) northwest of Hermosillo, Mexico, or and about 180 miles (285 km) south-southwest of Tucson, Arizona.
The continuing heavy rain led officials to close a section of the main federal highway connecting Mexico City to the region.
A hurricane watch is in effect from Punta Allen, Mexico, southward to the border between Belize and Guatemala.
Mexico suffered tens of millions in damage from Category 5 Hurricane Patricia, but ducked any major damage from eight other major hurricanes.
It will touch land in Sinaloa on Sunday.
The storm is centered about 570 miles (915 kilometers) south of Manzanillo, Mexico, and is moving west near 13 mph (20 kph).