Krisho Manoharan and Ruth Sang Jones, two natural science students at Leicester University, analysed the "minion genome" in the student journal of their university's Centre for Interdisciplinary Science. Through summarising the biological traits of minions and taking into account their supposed apparition on Earth some 400 million years ago, the students were able to speculate the make up of these cartoon characters genome. One of the possible components suggested were homoeotic genes, which are responsible for organism development. Jones and Manoharan event went as far as to study the proportions of minions, their small limbs and enlarged craniums appearing as possible symptoms of hypochondroplasia. This disease is usually caused by a mutation of the FGFR3 gene. The enlarged appearance of a minion's eyes, appearing to work more like a camera-lens than a human eye, can be linked to the Pax6 gene, responsible for eye and brain development. Mutations of this gene have been known to cause a variety of eye disorders. In humans, spoken articulation can be hindered by problems with the FoxP2 gene which potentially explains how the speech of the minions is broken and repetitive but despite its simplification, mirrors human language. Finally, Xanthophores are responsible for coloration of animals and therefore would be the cause of the bright yellow pigmentation of minions. If minions were a real species and not an animated character, it is semi-plausible that an evolutionary link may exist.